How To Repair Blood Vessels
Preventing and treating blood vessel damage
Diabetes damages blood vessels, and this tin accept devastating consequences. That's why nosotros're funding research that's all virtually keeping blood flowing properly.
Your trunk contains a threescore,000 mile network of blood vessels, with your heart at its centre. This incredible network is what delivers oxygen and other essential nutrients to every cell in your torso. Needless to say, it's pretty important that it works properly. Merely diabetes is a condition that tin play havoc with it. Diabetes leads to very loftier levels of sugar in the claret, and this can damage all blood vessels, including coronary arteries and smaller blood vessels. In some cases, this can lead to heartbreaking scenarios similar limb amputation, blindness and infertility. It is estimated that 4.eight million adults are living with diabetes in the UK.
Learning to live with a diabetes diagnosis
When Marc was diagnosed with Type 2 Diabetes on his 29th birthday it came as a huge daze, "My BMI was average and I wasn't classed as overweight. Although I would occasionally enjoy a few beers and takeaways I wouldn't say my diet was bloodcurdling." Only since then, the condition has had a huge impact on his life. He'due south at present partially sighted in his left eye, has fertility problems due to nervus damage, and he was forced to have his left leg amputated beneath the knee after a blister became infected. Since the amputation, Marc has faced an uphill struggle, "I felt actually anxious nigh going out and I would spend a lot of time at home... I nonetheless struggle with that confidence today." Despite everything, he tries to look on the bright side, "My family unit have been a large back up throughout. My daughter, Alice, has been not bad with it." and he's even joined an amputee football social club, "I've not but made some bully friends, but I've also had the opportunity to play at Manchester City'south training basis." Marc strongly advocates for early testing "I hope people to get tested as soon equally they take any symptoms considering the earlier you catch it, the easier it is to command".
Picture: Marc
Reducing blood vessel damage
Recently, we've been funding two enquiry teams that are focused on reducing claret vessel harm and helping people with diabetes to live longer, healthier lives. In Leeds, BHF Professor Mark Kearney and his colleagues accept found new ways to restore the ability of blood vessel cells to reply to insulin. This is important because diabetes impairs the body'south ability to brand or respond to insulin. And insulin is what helps to get sugar, a major source of energy, into cells and tissues. At present, Professor Kearney hopes to be able to develop new approaches to treatment of diabetes.
Meanwhile in Belfast, Professor Andriana Margariti has discovered a variant class of a factor that increases the risk of blood vessels becoming damaged past high blood saccharide levels. If a drug can exist developed to finish the effects of this variant gene, this could as well unlock a new way to prevent blood vessel damage in people with diabetes.
Growing new blood vessels
Peripheral arterial disease is when blood vessels in your legs and feet are damaged and become blocked, so the limbs don't go the claret supply they demand. It'due south a adequately common status and peculiarly in people over lx with diabetes. The most severe form is called critical limb ischaemia, which is very painful and can lead to amputation.
Several enquiry groups have explored whether injecting immune cells that can stimulate new blood vessel growth may be able to help patients merely so far, in that location has been little success. Now Professor Bijan Modarai, vascular surgeon and BHF Senior Fellow at King'south College London, is pioneering a new arroyo by injecting the cells inside "microcapsules". When tested in mouse models in 2022, this successfully prolonged the lifespan of the cells and induced new claret vessel germination that increased claret flow in the lower leg. It is hoped that this will atomic number 82 to clinical trials to assist patients with this astringent and difficult to treat condition.
Source: https://www.bhf.org.uk/what-we-do/birthday/preventing-and-treating-blood-vessel-damage
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